Компьютер­ный портал анализа экспрессии­ генов крысы

Hабор генов крысы, связанных с возрастной макулярной дегенерацией


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RGD_ID Название гена Описание Хромосома Начало Конец Transcript_ID Статья PubMed_ID
1304749Lrp6low density lipoprotein receptor-related protein 6encodes a putative receptor involved in the canonical Wnt receptor signaling pathway, cell-cell adhesion, synaptic transmission, and other processes; homologs are associated with metabolic syndrome, liver 4171337114171444932 .Haines JL, Schnetz-Boutaud N, Schmidt S, Scott WK, Agarwal A, Postel EA. et al. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci. 2006;47(1):329–35. PMID:16384981
1305630Elovl4ELOVL fatty acid elongase 488885515588881703 Conley YP, Thalamuthu A, Jakobsdottir J, Weeks DE, Mah T, Ferrell RE. et al. Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology of age-related maculopathy. Hum Mol Genet. 2005;14(14)PMID:15930014
1307477Mfrp membrane frizzled-related protein84708405647089218 Kameya S, Hawes NL, Chang B, Heckenlively JR, Naggert JK, Nishina PM. Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6. Hum Mol Genet 2002;11:1879–86. [PubMed: 12140190]PubMed: 12140190
1309445Abca4Abca4ATP-binding cassette, subfamily A (ABC1), member 4exhibits phospholipid transporter activity; involved in photoreceptor cell maintenance and visual perception (ortholog)2218712663218849896 Swaroop A, Branham KE, Chen W, Abecasis G.Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R174-82.PMID:17911160PMID:17911160
1309514Gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2, subunit of the G protein transducin; involved in transduction of signals resulting from bitter taste impulses in the tongue and visual impulses in retinal cones2203652408203655012 Chang B, Dacey MS, Hawes NL, Hitchcock PF, Milam AH, Atmaca-Sonmez P, Nusinowitz S, Heckenlively JR. Cone Photoreceptor Function Loss-3, a Novel Mouse Model of Achromotopsia Due to a Mutation in Gnat2. Invest Ophthalmol Vis Sci 2006;47:5017–21. [PubMed: 1PubMed: 17065522
1311509Ercc6Ercc6excision repair cross-complementing rodent repair deficiency, complementation group 61680248818091587 Baas DC, Despriet DD, Gorgels TG, Bergeron-Sawitzke J. The ERCC6 gene and age-related macular degeneration.PLoS One. 2010 Nov 1;5(11):e13786.PMID: 21072178PMID: 21072178
1561092Mdm1Mdm1 nuclear protein homolog (mouse)75745559857482092 Chang B, Mandal MN, Chavali VR, Hawes NL, Khan NW, Hurd RE, Smith RS, Davisson ML, Kopplin L, Klein BE, Klein R, Iyengar SK, Heckenlively JR, Ayyagari R. Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the MdmPubMed: 18805803
1564153Plekha1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 11190187202190238309 Conley YP, Jakobsdottir J, Mah T, et al. CFH, ELOVL4, PLEKHA1, and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses. Hum Mol Genet 2006;15:3206–3218. PubMed: 17000705PubMed:17000705
1564772Hmcn1hemicentin 1exhibits ATP and calcium ion binding, phsphatase activity, vascular endothelial growth factor receptor activity; involved in bioluminescence, dephosphorylation, protein-chromophore linkage (inferred)136529668265779372 Swaroop A, Branham KE, Chen W, Abecasis G.Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R174-82.PMID:17911160PMID:17911160
2129Apobapolipoprotein B, plays a role in cholesterol metabolism63150806031548083 Espinosa-Heidmann DG, Sall J, Hernandez EP, Cousins SW. Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E. Invest Ophthalmol Vis Sci 2004;45:260–6. [PubMed: 14691182]PubMed: 14691182
2138Apoeapolipoprotein E, plays a role in plasma lipoprotein transport17900363479006387 Baird PN, Richardson AJ, Robman LD, Dimitrov PN, Tikellis G, et al. 2006. Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD). Hum. Mutat. 27:337–42, PMID:16453339
2204CfbCfbcomplement factor Bcomponent of the alternative pathway of complement activation; may be linked to the major histocompatibility complex and thus involved in the immune response2040721244077802 Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, et al. 2006. Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat. Genet. 38:458–62. PMID:16518403PMID:16518403
2231C2complement component 2likely component of the classical pathway of the complement cascade; sequence is found within the major histocompatibility complex2040511464071909 Gold B, Merriam JE, Zernant J, et all.Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration.Nat Genet. 2006 Apr;38(4):458-62. Epub 2006 Mar 5. PMID:16518403
2232c3complement component 3, encodes a protein involved in the classical complement pathway, the positive regulation of ERK1 and ERK2 cascade, tolerance induction and other processes; associated with glomerulonephritis, myocardial infarction, pneumonia and ot????Maller, J.B., Fagerness, J.A., Reynolds, R.C., Neale, B.M., Daly, M.J., Seddon, J.M., 2007. Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat. Genet. 39, 1200–1201.PMID:17767156
2301Cd36CD36 molecule (thrombospondin receptor), a fatty acid translocase involved in long-chain fatty acid (LCFA) transport and regulation of angiogenesis; associated with atherosclerosis, diabetes mellitus, and other diseases41347187813525620 Kondo N, Honda S, Kuno S, Negi A., Positive association of common variants in CD36 with neovascular age-related macular degeneration.Aging (Albany NY). 2009 Feb 12;1(2):266-74., PMID:20157514PMID:20157514
2302Scarb1scavenger receptor class B, member 1, specific receptor for high density lipoprotein; may play a role in steroidogenesis123239018332457661 Zerbib J, Seddon JM, Richard F, et all, rs5888 variant of SCARB1 gene is a possible susceptibility factor for age-related macular degeneration.PLoS One. 2009 Oct 5;4(10):e7341.PMID:19806217PMID:19806217
2387Cpceruloplasmin (ferroxidase), copper-containing ferroxidase that promotes iron incorporation into transferrin; plays a role in iron metabolism and homeostatis2105086278105135367 Hadziahmetovic M, Dentchev T, Song Y, Haddad N, He X, Hahn P, Pratico D, Wen R, Harris ZL, Lambris JD, Beard J, Dunaief JL: Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Invest Ophthalmol Vis Sci 49(6):2728–2736, PMID:18326691
2432Cst3cystatin C, encodes a protein exhibiting cysteine-type endopeptidase inhibitor activity, protease binding, beta-amyloid binding (human ortholog); involved in positive regulation of cell proliferation, regulation of programmed cell death, response to oxida3137650903137654776 Alizadeh P, Smit-McBride Z, Oltjen SL, Hjelmeland LM., Regulation of cysteine cathepsin expression by oxidative stress in the retinal pigment epithelium/choroid of the mouse.Exp Eye Res. 2006 Sep;83(3):679-87. Epub 2006 May 8.PMID:16684524PMID:16684524
2594Fbln5fibulin 5may play a role in vascular growth and maturation during development and in lesions of injured vessels6126018541126098234 Mullins RF, Olvera MA, Clark AF, Stone EM.Fibulin-5 distribution in human eyes: relevance to age-related macular degeneration.Exp Eye Res. 2007 Feb;84(2):378-80. Epub 2006 Nov 14.PMID:17109857
2869Igf1rinsulin-like growth factor 1 receptor1122704976122990007 Chiu CJ, Conley YP, Gorin MB, Gensler G, Lai CQ, Shang F, Taylor A., Associations between genetic polymorphisms of insulin-like growth factor axis genes and risk for age-related macular degeneration.Invest Ophthalmol Vis Sci. 2011 Nov 25;52(12):9099-107. PMID:22058336
2870Igf2insulin-like growth factor 21202906624202915231 Chiu CJ, Conley YP, Gorin MB, Gensler G, Lai CQ, Shang F, Taylor A., Associations between genetic polymorphisms of insulin-like growth factor axis genes and risk for age-related macular degeneration.Invest Ophthalmol Vis Sci. 2011 Nov 25;52(12):9099-107. PMID:22058336
3009Lipclipase, hepatic, a lipase involved in the hydrolysis of phospholipids and triglycerides, developmental growth, lipoprotein remodeling and other processes; associated with diabetes, hyperlipidemia, kidney disease and other diseases; part of the reverse cho87532344275450353 Yu Y, Reynolds R, Fagerness J. Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration.Invest Ophthalmol Vis Sci. 2011 Jun 28;52(7):4663-70. Print 2011.PMID:21447678PMID:21447678
3645Ccl2chemokine (C-C motif) ligand 2, encodes a chemokine involved in the inflammatory response, organ regeneration, aging, and other processes; associated with arthritis, asthma, diabetes, and many other diseases107025626370258061 Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, et al. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med 2003b;9:1309–1398.
3731Sod1superoxide dismutase 1, soluble, catalyzes the conversion of superoxide to hydrogen peroxide and molecular oxygen; involved in response to oxidative stress112981076629816342 Imamura Y, Noda S, Hashizume K, Shinoda K, Yamaguchi M, Uchiyama S, Shimizu T, Mizushima Y, Shirasawa T, Tsubota K: Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degPMID:16844785
3732Sod2superoxide dismutase 2, mitochondrial, encodes a manganese-binding superoxide dismutase; involved in aging, hydrogen peroxide metabolic process, removal of superoxide radicals and other biological processes; associated with many diseases and many types of14186299741870327  SOD2 knockdown mouse model of early AMD. Invest Ophthalmol Vis Sci 48(10):4407–4420, 2007.PMID:17898259 PMID:17898259
3870Tlr4toll-like receptor 4encodes a lipopolysaccharide binding protein belonging to the toll-like receptor gene family; involved in response to toxin, positive regulation of NF-kappaB transcription factor activity, positive regulation of apoptosis and many othe58356410083577735 Swaroop A, Branham KE, Chen W, Abecasis G.Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R174-82.PMID:17911160PMID:17911160
3963Vldlrvery low density lipoprotein receptor, encodes a protein exhibiting protein tyrosine kinase activator activity, very-low-density lipoprotein receptor activity (human ortholog), protein binding (Dab1; mouse ortholog) and other functions (inferred); involve1230666736230697748 Haines JL, Schnetz-Boutaud N. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6.Invest Ophthalmol Vis Sci. 2006 Jan;47(1):329-35.PMID:16384981
619799Vegfbvascular endothelial growth factor B, mouse homolog is a growth factor; involved in the promotion of angiogenesis1209657632209661271 Boltz A, Rui? M, Jonas JB, Tao Y, Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration., Ophthalmology. 2012 Apr 20. [Epub ahead of print]PMID:22521084
619991Vegfavascular endothelial growth factor Amediates broad spectrum of biological processes, including stimulating cell proliferation, inducing cell migration, promoting cell survival, and regulating physiological and pathological angiogenesis91052073010536071 Swaroop A, Branham KE, Chen W, Abecasis G.Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R174-82.PMID:17911160PMID:17911160
619991Vegfavascular endothelial growth factor A, mediates broad spectrum of biological processes, including stimulating cell proliferation, inducing cell migration, promoting cell survival, and regulating physiological and pathological angiogenesis91052073010536071 Schwesinger C, Yee C, Rohan RM, Joussen AM, Fernandez A, Meyer TN, Poulaki V, Ma JJ, Redmond TM, Liu S, Adamis AP, D’Amato RJ: Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epPMID:11238064
620137Cx3cr1chemokine (C-X3-C motif) receptor 1member of the rhodopsin family of G-protein coupled receptors; may act as a receptor for a chemokine peptide ligand8125033630125047335 Swaroop A, Branham KE, Chen W, Abecasis G.Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R174-82.PMID:17911160PMID:17911160
620137Cx3cr1 chemokine (C-X3-C motif) receptor 1, member of the rhodopsin family of G-protein coupled receptors; may act as a receptor for a chemokine peptide ligand8125033630125047335 Chen Y, Bedell M, Zhang K., Age-related macular degeneration: genetic and environmental factors of disease., Mol Interv. 2010 Oct;10(5):271-81.,PMID:21045241 PMID:21045241
620428Cfh complement factor H, regulator of complement cascade activation135325224953355987 Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, et al. 2005. Complement factor H variant increases the risk of age-related macular degeneration. Science 308:419–21PMID:15761120
620429Cficomplement factor Imouse homolog is a regulatory serine proteinase of the complement cascade that cleaves C3b and C4b and inactivates them2227281621227325109 Fagerness JA, Maller JB. Variation near complement factor I is associated with risk of advanced AMD.Eur J Hum Genet. 2009 Jan;17(1):100-4. Epub 2008 Aug 6. PMID:18685559
620876Ccr2 chemokine (C-C motif) receptor 2, mediates leukocyte migration and activation8128892784128893905 Ramkumar HL, Zhang J, Chan CC., Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).Prog Retin Eye Res. 2010 May;29(3):169-90. Epub 2010 Mar 3., PMID:20206286PMID:20206286
621320 Mmp9matrix metallopeptidase 9, encodes a metalloproteinase involved in regulation of angiogenesis, regulation of cell migration, and other biological processes; associated arteriosclerosis, arthritis, brain injuries and many other diseases3155985473155993433 Hendrik P.N. Scholl,et all, An update on the genetics of age-related macular degeneration., Mol Vis. 2007 Feb 7;13:196-205., PMID:17327825PMID:17327825
735171Tlr3toll-like receptor 3encodes a protein exhibiting receptor activity, double-stranded RNA binding, protein binding (Unc93b1; mouse ortholog); involved in microglial cell activation involved in immune response, positive regulation of apoptosis, toll-like rec165011291050126371 Swaroop A, Branham KE, Chen W, Abecasis G.Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R174-82.PMID:17911160PMID:17911160
735225Serping1serpin peptidase inhibitor, clade G, member 1; human homolog acts as a serine protease inhibitor; involved in regulation of the classical complement pathway36796880867978102 Nakata I, Yamashiro K, Yamada R et all, Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese.PLoS One. 2011 Apr 19;6(4):e19108.PMID:21526158PMID:21526158